Protein Production Services
Quality proteins,
quality projects
Producing high quality protein is the foundation of many scientific projects. We are proud to have a protein science facility furnished with state-of-the-art equipment coupled with an experienced team of scientists. We have a proven track record of expressing and purifying material across an extensive range of protein classes using innovative target-dependent approaches.
Protein production that drives science
Our protein production services deliver high-quality, characterised protein at every stage of the drug discovery process, from initial construct design to crystallographic-grade material for structure determination.
Protein Expression
Versatile protein expression services across multiple systems, optimised to maximise yield, quality and construct selection for every target.
- Multiple expression systems: E. coli, yeast, insect and mammalian cell
- Co-expression with binding partners; plate-based construct and mutant screening
- Bioreactor for precise control of growth conditions and optimal yield
Protein Purification
Over 25 years of experience purifying a wide range of protein classes, including difficult-to-express proteins and multi-subunit complexes.
- Full chromatographic techniques: affinity, IEX, HIC, reverse-phase and SEC
- State-of-the-art AKTA Pure and Avant chromatography systems
- Site-specific labelling with biotin, fluorophores and DBCO; >70 protein targets crystallised
Quality Control
Comprehensive protein quality control using high-resolution mass spectrometry and biophysical characterisation to confirm material suitability.
- High resolution mass spectrometry (Agilent QTOF): intact mass, native mass and peptide mass fingerprinting
- Analytical SEC, NMR fold assessment and differential scanning fluorimetry (DSF)
- SDS-PAGE, biochemical assays and isotopic labelling (15N, 13C, 2H)
Isotopic Labelling
Isotopic labelling services support advanced NMR studies, enabling backbone and side-chain assignments and detailed structural characterisation.
- 15N, 13C and 2H labelling for NMR structural studies
- Optimisation of expression and purification for labelled material
- Quality assessment of labelled protein by mass spectrometry and NMR
Integrated Drug Discovery
Turning discovery potential into clinical promise
From construct design to protein production, our team delivers the high-quality reagents your programme needs — engineered for biophysical, structural and screening applications.
Biology Foundations
Structure & Hit ID
DEL Services
Chemistry & Data
Preclinical Readiness
Why work with us
Delivering the right material for every downstream application
Our protein science team has expressed and purified material from an extensive range of target classes, including kinases, proteases, secreted proteins and multi-subunit complexes. With over 70 targets crystallised and a proven record of producing challenging proteins, we deliver the right material for every downstream application — from screening to structural studies.
Meet the Protein Sciences team:
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Ed Carter PhD
Team Leader, Protein Science
Ed Carter PhD
Team Leader, Protein Science
Dr Edward Carter is a Team Leader in Protein Science at Vernalis having joined the company in 2017. He completed his PhD at the University of Kent and since then has gained experience across the pharma, biotech and start-up industries at Pfizer, MedImmune and Adaptimmune. During his career, Ed has had the opportunity to help develop novel biologics that have been tested in clinical trials and has contributed to patents on the development of T cell receptors. Ed and his team are focused on the production of high-quality proteins to enable biophysical and structural studies.
Protein Science Case Studies
Explore how our Protein Science team overcomes challenges through case studies demonstrating high‑quality protein production.
Unlock your protein’s full potential
We’d love to hear from you! Head to our contact page to get started.