Drug Discovery Resources
Smarter discovery.
Sharper understanding.
Guides, insights and technical resources designed to support informed decisions throughout the drug discovery journey.
Case Studies
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Hsp90 oral backup pre-clinical candidate
Fragment-based and in silico hits were combined into a novel series of Hsp90 inhibitors, delivering tumour growth regression on oral dosing in a BT474 xenograft model.
Outcome Oral pre-clinical candidate — the follow-on to the intravenous phase II compound. -
DYRK1A and DYRK1B selective inhibitors
A Vernalis and Servier NMR fragment screen delivered two series of potent, selective DYRK1A inhibitors, including the brain-penetrant tool compound 34.
Outcome Two optimised inhibitor series and a selective, brain-penetrant tool compound.
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Publications
Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening
Tasdan, Y. et al., J. Med. Chem. 2026
Read on ACS PublicationsStructure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding
Timari, M. P. et al., J. Med. Chem. 2026
Read on ACS PublicationsWant to explore a specific topic?
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