Drug Discovery Articles
Proven science.
Published excellence.
Peer‑reviewed publications demonstrating our rigour, innovation and contribution to discovery across multiple therapeutic areas.
Publications
Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening
Tasdan, Y. et al., J. Med. Chem. 2026
Read on ACS PublicationsStructure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding
Timari, M. P. et al., J. Med. Chem. 2026
Read on ACS PublicationsTargeting PTPN22 at Nonorthosteric Binding Sites─A Fragment Approach
Di Lello, P. et al., ACS Omega 2026, 11, 2, 3465–3480
Read on ACS PublicationsChemically Induced Nuclear Pore Complex Protein Degradation via TRIM21
Li, X. et al., ACS Chem. Biol. 2025
Read on ACS PublicationsEnabling organometallic libraries by flow: A tale of two metals
Maddox, D. et al., React. Chem. Eng. 2024, 9, 1656–1665
Read on RSC PublishingA covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase
Kuki, N. et al., RSC Med. Chem. 2023, 14, 2731–2737
Read on RSC PublishingPAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery
Ma, H. et al., RSC Med. Chem. 2022, 13, 1341–1349
Read on RSC PublishingDesign and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate
Williamson, D. S. et al., J. Med. Chem. 2021, 64, 10312–10332
Read on ACS PublicationsFragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B
Walmsley, D. L. et al., J. Med. Chem. 2021, 64, 8971–8991
Read on ACS PublicationsStructure-Guided Discovery of Potent and Selective DYRK1A Inhibitors
Weber, C. et al., J. Med. Chem. 2021, 64, 6745–6764
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